- Isomannide
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- $120.00
-
2026-02-02
- CAS:641-74-7
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 200tons
- Isomannide
-
-
2022-02-22
- CAS:641-74-7
- Min. Order: 1KG
- Purity: 98.8%
- Supply Ability: 100 tons
- Isomannide
-
- $1.00
-
2019-12-26
- CAS:641-74-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | Isomannide Basic information |
| Product Name: | Isomannide | | Synonyms: | 1,4:3,6-DIANHYDROMANNITOL;ISOMANNIDE;Perhydro-3,6-dihydroxyfuro[3,2-b]furan;Keratin 5 &;Milnacipran Impurity 14;(3R,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol;I**isomannide、1,4:3,6-dianhydro-D-manni;3-Nitro-4-hydroxy diphenyl | | CAS: | 641-74-7 | | MF: | C6H10O4 | | MW: | 146.14 | | EINECS: | 211-374-1 | | Product Categories: | Heterocycles;Alcohols and Derivatives;Glycon Biochem | | Mol File: | 641-74-7.mol |  |
| | Isomannide Chemical Properties |
| Melting point | 80-85 °C (lit.) | | alpha | 89 º (c=3, H2O) | | Boiling point | 150 °C / 12mmHg | | density | 1.0945 (rough estimate) | | refractive index | 1.4128 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly), Water | | form | Solid | | pka | 13.17±0.40(Predicted) | | color | White to Off-White | | Optical Rotation | [α]25/D +89°, c = 3 in H2O | | Water Solubility | almost transparency | | BRN | 80509 | | InChI | 1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4-,5-,6-/m1/s1 | | InChIKey | KLDXJTOLSGUMSJ-KVTDHHQDSA-N | | SMILES | O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12 | | CAS DataBase Reference | 641-74-7(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | Isomannide Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | 1,4:3,6-Dianhydro-D-mannitol is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis. | | Synthesis | The general procedure for the synthesis of 1,4:3,6-bis-anhydromannitol from D-mannitol was as follows: 1350 g of crystalline D-mannitol was added to a reduced-pressure reactor equipped with a stirrer and heated to 170 °C to melt it. Subsequently, 10 g of 98% concentrated sulfuric acid was added to the melt, and the reaction lasted for 20 h at 170 °C and 2 kPa with nitrogen gas being passed at a flow rate of 200 mL/min. Upon completion of the reaction, the product was cooled to 90 °C and 30 g of 48% (w/w) aqueous sodium hydroxide solution was added to give crude 1,4:3,6-bis-anhydromannitol. Next, 39 g of horseshoe-based wood activated carbon (trade name: Tyco K, produced by Futamura Chemical Co., Ltd.) was added to the crude product and stirred for 3 h for decolorization to obtain a mixture to be distilled. Water was distilled from the mixture at 120 °C and 5 kPa. Subsequently, a reduced pressure distillation was carried out at 170 °C and 0.3 kPa under reduced pressure by passing nitrogen at a flow rate of 200 mL/min, resulting in 491 g of product. A portion of the distilled product was taken and the pH of the mixture was determined to be 10 according to the method of Example 1. | | References | [1] Green Chemistry, 2015, vol. 17, # 2, p. A1176 - A1185
[2] Journal of Chemical Crystallography, 1997, vol. 27, # 3, p. 161 - 166
[3] Carbohydrate Research, 1980, vol. 79, p. 133 - 141
[4] Journal of Organometallic Chemistry, 1983, vol. 253, # 2, p. 249 - 252
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 930,934 |
| | Isomannide Preparation Products And Raw materials |
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