- 2,5-Difluoroaniline
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- $50.00 / 1KG
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2025-09-25
- CAS:367-30-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2,5-Difluoroaniline
-
- $1.00 / 1KG
-
2024-06-18
- CAS:367-30-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20t
- 2,5-Difluoroaniline
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- $0.00 / 1KG
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2022-02-21
- CAS:367-30-6
- Min. Order: 1KG
- Purity: 99.3%
- Supply Ability: 100 tons
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| | 2,5-Difluoroaniline Basic information |
| Product Name: | 2,5-Difluoroaniline | | Synonyms: | Aniline, 2,5-difluoro-;2,5-DIFLUOROANILINE;2,5-DIFLUOROBENZENAMINE;2,5-Difluoroaniline 98%;2,5-Difluoroaniline,98%;Difluoroaniline3;2,5-DIFLUOROANILINE, 99.5%;Benzenamine, 2,5-difluoro- | | CAS: | 367-30-6 | | MF: | C6H5F2N | | MW: | 129.11 | | EINECS: | 206-690-1 | | Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;Aniline;Fluorobenzene;Miscellaneous;Amines;C2 to C6;Nitrogen Compounds;bc0001 | | Mol File: | 367-30-6.mol |  |
| | 2,5-Difluoroaniline Chemical Properties |
| Melting point | 11-13 °C (lit.) | | Boiling point | 176-178 °C (lit.) | | density | 1.288 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.513(lit.) | | Fp | 156 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 2.19±0.10(Predicted) | | form | clear liquid | | color | Colorless to Yellow to Orange | | Specific Gravity | 1.29 | | Water Solubility | Not miscible in water. | | BRN | 2802549 | | InChI | InChI=1S/C6H5F2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2 | | InChIKey | YNOOQIUSYGWMSS-UHFFFAOYSA-N | | SMILES | C1(N)=CC(F)=CC=C1F | | CAS DataBase Reference | 367-30-6(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenamine, 2,5-difluoro-(367-30-6) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 28-36/37/39-26-36 | | RIDADR | 2941 | | WGK Germany | 3 | | F | 8-10-23 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214210 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Skin Sens. 1 |
| | 2,5-Difluoroaniline Usage And Synthesis |
| Chemical Properties | clear brown liquid | | Uses | 2,5-Difluoroaniline was used in the synthesis of 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol. It was also used in ultrasound-assisted preparation of 1,4-diazabutadienes. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. | | Synthesis | General procedure for the synthesis of 2,5-difluoroaniline from 2,5-difluoronitrobenzene: To a solution of 1,4-difluoro-2-nitrobenzene (500 mg, 3.14 mmol) in methanol (20 mL) was added palladium/carbon catalyst (66.9 mg, 0.629 mmol) in batches. Subsequently, the reaction mixture was stirred at 20 °C for 1 h under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC, petroleum ether/ethyl acetate = 3/1) and after confirming the complete consumption of raw materials, the reaction mixture was filtered. The filtrate was concentrated to afford the target product 2,5-difluoroaniline (338 mg, 2.61 mmol, 83% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.94-6.88 (m, 1H), 6.50-6.46 (m, 1H), 6.40-6.31 (m, 1H), 3.82 (br.s., 2H). | | References | [1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0485; 0486
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 109
[3] Recueil des Travaux Chimiques des Pays-Bas, 1914, vol. 33, p. 299
[4] Chem. Zentralbl., 1914, vol. 85, # II, p. 320
[5] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111 |
| | 2,5-Difluoroaniline Preparation Products And Raw materials |
| Raw materials | Nitric acid-->Iron-->1,4-Difluorobenzene-->2,5-Difluoronitrobenzene | | Preparation Products | 4-BROMO-2,5-DIFLUOROBENZENESULFONYL CHLORIDE-->2,5-Difluoronitrobenzene-->2,5-Difluorophenol-->4-BROMO-2,5-DIFLUOROIODOBENZENE-->4,7-DIFLUOROISATIN-->2,5-DIFLUOROIODOBENZENE-->2,5-Difluorophenylene-1,4-diamine, 1,4-Diamino-2,5-difluorobenzene-->ethyl 2-(2,5-difluoroanilino)-2-oxoacetate-->5-Bromo-4,7-difluoro-1H-indazole-3-carboxylic acid-->N-(2,5-Difluoro-phenyl)-forMaMide |
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