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| | BETA-HYDROXYISOVALERYLSHIKONIN Basic information |
| Product Name: | BETA-HYDROXYISOVALERYLSHIKONIN | | Synonyms: | BETA-HYDROXYISOVALERYLSHIKONIN;BETA-HYDROXYISOVALERYSHIKONIN;3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester;5,8-Dihydroxy-2-[(R)-1-[(3-hydroxy-3-methylbutanoyl)oxy]-4-methyl-3-pentenyl]-1,4-naphthalenedione;β-HIVS;β-Hydroxyisovalerylshikonin;Beta-Hydroxylsovalerylshikonin;β-hydroxylsovalerylshikonin | | CAS: | 7415-78-3 | | MF: | C21H24O7 | | MW: | 388.41 | | EINECS: | | | Product Categories: | | | Mol File: | 7415-78-3.mol |  |
| | BETA-HYDROXYISOVALERYLSHIKONIN Chemical Properties |
| Melting point | 90-92 °C | | Boiling point | 616.9±55.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | pka | 7.08±0.20(Predicted) | | form | Solid | | color | Brown to black | | LogP | 2.424 (est) |
| | BETA-HYDROXYISOVALERYLSHIKONIN Usage And Synthesis |
| Uses | Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1]. | | References | [1] Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51. DOI:10.1111/j.1349-7006.2002.tb01341.x |
| | BETA-HYDROXYISOVALERYLSHIKONIN Preparation Products And Raw materials |
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