(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol

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(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol Basic information
Product Name:(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol
Synonyms:(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol;1-Pentanol, 3-methyl-2-[methyl(phenylmethyl)amino]-, (2S,3S)-;Monomethyl auristatin E intermediate-11;(2S,3S)-3-Methyl-2-[methyl(phenylmethyl)amino]-1-pentanol
CAS:870640-62-3
MF:C14H23NO
MW:221.34
EINECS:
Product Categories:
Mol File:870640-62-3.mol
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol Structure
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol Chemical Properties
Boiling point 313.6±17.0 °C(Predicted)
density 0.975±0.06 g/cm3(Predicted)
pka14.71±0.10(Predicted)
form Oil
color Colorless to light yellow
Safety Information
MSDS Information
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol Usage And Synthesis
UsesMonomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
References[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931
(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol Preparation Products And Raw materials
Tag:(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol(870640-62-3) Related Product Information
N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Z-MeIle-OH Carbamic acid, N-[(1R,2S)-1-(hydroxymethyl)-2-methylbutyl]-, phenylmethyl ester RIESWPZCQMFUMF-WCQYABFASA-N RIESWPZCQMFUMF-DGCLKSJQSA-N Carbamic acid, N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]-, phenylmethyl ester