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Aminodiphenylmethane hydrochloride

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Aminodiphenylmethane hydrochloride Basic information
Product Name:Aminodiphenylmethane hydrochloride
Synonyms:1,1-DIPHENYLMETHYLAMINE HYDROCHLORIDE;benzhydrylammonium chloride;a-diphenylamine hydrochloride;BenzhydrylamineHCl,(Aminodiphenylmethanehydrochloride);alpha-Aminodiphenylme;Benzenemethanamine, .alpha.-phenyl-, hydrochloride;BENZHYDRYLAMINEHCL;Aminodiphenylmethane hydrochloride,97%
CAS:5267-34-5
MF:C13H14ClN
MW:219.71
EINECS:226-084-0
Product Categories:Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
Mol File:5267-34-5.mol
Aminodiphenylmethane hydrochloride Structure
Aminodiphenylmethane hydrochloride Chemical Properties
Melting point 293-295 °C(lit.)
Boiling point 205-207 °C(Press: 4 Torr)
storage temp. Inert atmosphere,Room Temperature
form powder to crystal
color White to Almost white
Sensitive Hygroscopic
Merck 14,1076
BRN 3914818
InChI1S/C13H13N.ClH/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10,13H,14H2;1H
InChIKeyCIHWJRSPVJBHGT-UHFFFAOYSA-N
SMILESCl.NC(c1ccccc1)c2ccccc2
CAS DataBase Reference5267-34-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
HS Code 29214990
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Aminodiphenylmethane hydrochloride Usage And Synthesis
Chemical Propertieswhite to off-white crystalline powder
UsesBenzhydrylamine Hydrochloride is used as molecular tools to block maturation of nuclear lamin A and decelerate cancer cell migration.
Synthesis
Benzophenone oxime

574-66-3

Aminodiphenylmethane hydrochloride

5267-34-5

In the second step, benzophenone oxime (900 mg) was hydrogenated with a solution of concentrated hydrochloric acid (1.84 mL) in ethanol (50 mL) at atmospheric pressure in the presence of 10% Pd/C catalyst (100 mg). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated. The concentrated residue was suspended in ethyl acetate and the suspension was filtered again to give the final diphenylmethylamine hydrochloride (2.17 g) as a white solid.

References[1] Patent: EP2511283, 2012, A1. Location in patent: Page/Page column 91
[2] Patent: US2013/45942, 2013, A1. Location in patent: Paragraph 0379
[3] Patent: JP2015/172077, 2015, A. Location in patent: Paragraph 0187
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