BCI manufacturers
- BCI
-
- $48.00
-
2026-07-27
- CAS:1245792-51-1
- Purity: 99.95%
- Supply Ability: 10g
- BCI
-
- $48.00
-
2026-07-27
- CAS:1245792-51-1
- Purity: 99.95%
- Supply Ability: 10g
- BCI
-
-
2026-06-30
- CAS:1245792-51-1
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 10000KGS
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| Product Name: | BCI | | Synonyms: | BCI;BCI - NSC 150117;1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-, (2E)-;inhibit,Phosphatase,BCI,Inhibitor;BCI, 10 mM in DMSO;(2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone;BCI ((E)-BCI);(E)-BCI | | CAS: | 1245792-51-1 | | MF: | C22H23NO | | MW: | 317.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1245792-51-1.mol |  |
| storage temp. | Store at -20°C | | solubility | DMSO:125.0(Max Conc. mg/mL);393.79(Max Conc. mM) | | form | Solid | | color | Off-white to yellow |
| Description | BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively. | | Uses | BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2]. | | Definition | ChEBI: (2E)-2-benzylidene-3-(cyclohexylamino)indan-1-one is a 2-benzylidene-3-(cyclohexylamino)indan-1-one in which the double bond has E configuration. An inhibitor of the dual specificity phosphatase 6 (Dusp6). It has a role as an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and an apoptosis inducer. | | References | [1] Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45. DOI:10.1002/cbic.201402000
[2] Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681. DOI:10.1007/s10753-018-0924-2 |
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