PNU 22394 hydrochloride

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Company Name: Nanjing Chemlin Chemical Co., Ltd  
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PNU 22394 hydrochloride Basic information
Product Name:PNU 22394 hydrochloride
Synonyms:6-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole hydrochloride
CAS:15923-42-9
MF:C13H17ClN2
MW:236.74
EINECS:
Product Categories:
Mol File:15923-42-9.mol
PNU 22394 hydrochloride Structure
PNU 22394 hydrochloride Chemical Properties
storage temp. Store at -20°C
form Powder
color White to off-white
Water Solubility Soluble to 100 mM in water
Safety Information
MSDS Information
PNU 22394 hydrochloride Usage And Synthesis
UsesPNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively[1].
in vivo

PNU-22394 hydrochloride exhibits agonistic efficacy for 5-HT2C and 5-HT2A, with EC50 of 7.7 and 23 nM (measured via the Fluo-4/Ca2+ Assay), or 0.12 and 0.21 μM (measured via IP-One Assay), while the Rmax is 97%-102%[2].

References[1] Ennis MD, et al., 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2369-72. DOI:10.1016/s0960-894x(03)00403-7
[2] Jensen AA, et al., Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56(3):1211-27. DOI:10.1021/jm301656h
PNU 22394 hydrochloride Preparation Products And Raw materials
Tag:PNU 22394 hydrochloride(15923-42-9) Related Product Information
9-[3-(p-Fluorobenzoyl)propyl]-5-methyl-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro- Cyclopent[b]indole, 1,2,3,4-tetrahydro-4-methyl- Pyrido[1,2-a]indole-10-ethanamine, 6,7,8,9-tetrahydro- 8-Bromo-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Indole, 2-[2-(dimethylamino)ethyl]-3-ethyl-1-methyl- (8CI)