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| | 5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Basic information |
| Product Name: | 5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE | | Synonyms: | 5-FLUORO-3-(1H)INDAZOLE CARBOXALDEHYDE;5-FLUORO INDAZOLE-3-CARBOXALDEHYDE;5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE;5-Fluoro-3-(1H)indazolecarboxyaldehyde;1H-Indazole-3-carboxaldehyde,5-fluoro-(9CI);5-fluoro-1H-Indazole-3-carboxaldehyde;5-fluoro-2H-indazole-3-carboxaldehyde;1H-Indazole-3-carboxaldehyde, 5-fluoro- | | CAS: | 485841-48-3 | | MF: | C8H5FN2O | | MW: | 164.14 | | EINECS: | | | Product Categories: | HALIDE;Indazoles | | Mol File: | 485841-48-3.mol |  |
| | 5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to light brown Solid |
| | 5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Usage And Synthesis |
| Uses | 5-fluoro-1H-indazole-3-carbaldehyde is used as a key intermediate in the synthesis of a variety of polyfunctionalized 3-substituted indazoles. | | Synthesis | Step 3: Manganese dioxide (1.12 g, 12.9 mmol) was added to a solution of (5-fluoro-1H-indazol-3-yl)methanol (0.215 g, 1.29 mmol) in ethyl acetate (10 mL) at room temperature. The reaction mixture was stirred overnight and filtered through diatomaceous earth. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: chloroform/methanol) to afford 5-fluoro-1H-indazole-3-carbaldehyde (0.150 g, 70% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.41 (ddd, J = 2.2,8.8,9.5 Hz, 1H), 7.75-7.81 (m, 2H), 10.18 (s, 1H), 14.32 (br s, 1H). | | References | [1] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0352 |
| | 5-FLUORO-1H-INDAZOLE-3-CARBALDEHYDE Preparation Products And Raw materials |
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