CAY10647

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CAY10647 Suppliers list
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
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Company Name: Jilin Chinese Academy of Sciences-yanshen Technology  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.cn
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology  
Tel: 18143011203
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CAY10647 Basic information
Product Name:CAY10647
Synonyms:CAY10647;CAY10647 Exclusive;(4-fluorophenyl)-[2-(4-methoxyphenyl)-1H-imidazol-5-yl]methanone;(4-fluorophenyl)(2-(4-methoxyphenyl)-1H-imidazol-4-yl)methanone;Methanone, (4-fluorophenyl)[2-(4-methoxyphenyl)-1H-imidazol-5-yl]-;Anti-melanoma agent 3
CAS:1253697-49-2
MF:C17H13FN2O2
MW:296.3
EINECS:
Product Categories:
Mol File:1253697-49-2.mol
CAY10647 Structure
CAY10647 Chemical Properties
Melting point 245-247 °C(Solv: water (7732-18-5); methanol (67-56-1))
Boiling point 521.2±40.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
solubility DMF: 3 mg/ml; DMSO: 3 mg/ml
form A crystalline solid
pka10.75±0.10(Predicted)
Safety Information
MSDS Information
CAY10647 Usage And Synthesis
UsesAnti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization[1].
in vivo

Anti-melanoma agent 3 (10, 30 mg/kg; ip; once a day for 14 days) can significantly inhibit tumor growth in B16-F1 tumor-bearing mice[1].

References[1] Chen J, et al. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem. 2010 Oct 28;53(20):7414-27. DOI:10.1021/jm100884b
CAY10647 Preparation Products And Raw materials
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