| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Cckinase, Inc. |
| Tel: |
+1 (732)236-3202 |
| Email: |
sales@cckinase.com |
|
| | IWP-2-V2 Basic information |
| Product Name: | IWP-2-V2 | | Synonyms: | IWP-2-V2;INHIBITOR OF WNT PRODUCTION-2-V2;CS-1444;N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-4-oxo-3-(phenylmethyl)thieno[3,2-d]pyrimidin-2-yl]thio]-acetamide;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-4-oxo-3-(phenylmethyl)thieno[3,2-d]pyrimidin-2-yl]thio]- | | CAS: | 877618-79-6 | | MF: | C23H20N4O2S3 | | MW: | 480.63 | | EINECS: | | | Product Categories: | | | Mol File: | 877618-79-6.mol |  |
| | IWP-2-V2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤2mg/ml in DMSO;5mg/ml in dimethyl formamide | | form | crystalline solid |
| | IWP-2-V2 Usage And Synthesis |
| Uses | IWP-2-V2 is a IWP-2 (HY-13912) analogue that retains activity against the Wnt/β-catenin pathway[1]. | | Biological Activity | iwp-2-v2 is a wnt production inhibitor.wnt signaling proteins are small secreted proteins that are active in tissue homeostasis, embryonic development, and tumorigenesis. wnt proteins bind to receptors, initiating a signaling cascade that results in β-catenin activation of gene transcription. | | in vitro | iwp-2 was identified as an inhibitor of wnt production inactivating porcupine, a membrane-bound o-acyltransferase whose palmitoylation activity was essential for the signaling ability and secretion of wnt proteins. iwp-2-v2 is a less potent iwp-2 derivative whose chemical structure retains the benzothiazole group of its parent compound. iwp-2-v2 was used to evaluate which structural features of iwp-2 were critical for impairing wnt/β-catenin pathway activity [1]. | | in vivo | in cci rats, repetitive i.t. administration of iwp-2 (20 μm) in the early phase could significantly delay production of mechanical allodynia. the same drug administrated in the late phase produced long-lasting inhibitory effects on the established mechanical allodynia. such analgesia lasted 4–6 days for iwp-2 after termination of the third treatment. these results showed similar inhibitory effects of iwp-2 on thermal hyperalgesia after cci treatment [2]. | | IC 50 | 27 nm | | references | [1] b. chen, m. e. dodge, w. tang, et al. small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. nature chemical biology 5(2), 100-107 (2009).
[2] y. zhang et al. wnt signaling underlies the pathogenesis of neuropathic pain in rodents. j clin invest. 2013 may 1; 123(5): 2268–2286. |
| | IWP-2-V2 Preparation Products And Raw materials |
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