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| | Methylprednisolone acetate Basic information |
| Product Name: | Methylprednisolone acetate | | Synonyms: | depo-medrone;Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6.alpha.,11.beta.)-;METHYLPREDNISOLONEACETATE,MICRONIZED,USP;21-Acetoxy-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione;6a-Methylprednisolone 21-acetate;DepMedalone 40;DepMedalone 80;Mepred | | CAS: | 53-36-1 | | MF: | C24H32O6 | | MW: | 416.51 | | EINECS: | 200-171-3 | | Product Categories: | API;Miscellaneous Biochemicals;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;53-36-1 | | Mol File: | 53-36-1.mol |  |
| | Methylprednisolone acetate Chemical Properties |
| Melting point | 192-195°C | | alpha | D20 +101° (dioxane) | | Boiling point | 454.82°C (rough estimate) | | density | 1.1156 (rough estimate) | | refractive index | 1.4593 (estimate) | | storage temp. | Refrigerator | | solubility | Practically insoluble in water, sparingly soluble in acetone and in ethanol (96 per cent). | | pka | 12.41±0.70(Predicted) | | form | Solid | | color | White to Off-White | | Optical Rotation | [α]/D 85 to 105°, c =0.5 in chloroform-d | | InChIKey | PLBHSZGDDKCEHR-OJNHZLOINA-N | | SMILES | [C@@]12([H])C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C)O)C |&1:0,3,10,12,14,16,18,21,r| | | CAS DataBase Reference | 53-36-1(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 63-62 | | Safety Statements | 36/37-24/25 | | WGK Germany | WGK 3 | | HS Code | 32041200 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Repr. 2 | | Toxicity | LD50 oral in rat: > 10gm/kg |
| | Methylprednisolone acetate Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Methylprednisolone acetate is used as a glucocorticoid. | | Uses | 6α-Methyl Prednisolone 21-Acetate is used as a glucocorticoid. | | Definition | ChEBI: An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid. | | Brand name | Medrol (Pharmacia & Upjohn). | | Biological Activity | Long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses.
Methylprednisolone acetate (Depo-Medrol) is a long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses. 6-Methylprednisolone acetate binds to intracellular glucocorticoid receptors and inhibits promoter domains of pro-inflammatory genes and hinders secretion of inflammatory cytokines. It effectively treats multiple ailments such as rheumatic and autoimmune diseases, leukemia, multiple myeloma, and Hodgkin's and non-Hodgkin's lymphoma symptoms along with other drugs. MPA improves COVID-19 pneumonia prognosis. | | Toxics Screening Level | The initial threshold screening level (ITSL) for methylpredisolone acetate is 43 μg/m3 based on an annual averaging time. |
| | Methylprednisolone acetate Preparation Products And Raw materials |
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