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| Product Name: | 4E-BP1 | | Synonyms: | Anti-4E-BP1, N-Terminal antibody produced in rabbit;PHAS-I;4E-BP1;ELF-4E BINDING PROTEIN 1;Eukaryotic translation initiation factor 4E binding protein 1;EIF4EBP1;Insulin-stimulated EIF-4E binding protein PHAS-I;P/OKCL.6 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![4E-BP1 Structure]() |
| | 4E-BP1 Chemical Properties |
| storage temp. | -20°C | | form | aqueous solution | | biological source | human |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | 4E-BP1 Usage And Synthesis |
| Uses | 4EBP1 Active human has been used as a substrate for in vitro kinase assay. | | Biological Activity | E1F4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is involved in protein synthesis, cell growth and survival. In unphosphorylated form, it suppresses the translation initiation of capped mRNAs. On the other hand, in phosphorylated form, it increases translation initiation. Phosphorylation of E1F4EBP1 releases it from eIF4E (eukaryotic translation initiation factor 4E), thereby resulting in cap-dependent translation. E1F4EBP1 is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It is also a substrate for mTORC1 (mammalian target of rapamycin complex 1). In non-phosphorylated conditions, it interacts with p21 (cyclin-dependent kinase inhibitor) and enhances destabilization of p21. |
| | 4E-BP1 Preparation Products And Raw materials |
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