432499-63-3
| 中文名称 | 432499-63-3 |
|---|---|
| 中文同义词 | 5-(5-((3-苄基-4-氧代-2-硫噻唑烷-5-亚基)甲基)呋喃-2-基)-2-氯苯甲酸;化合物 T14044;化合物4E2RCAT;化合物4E2RCAT,10 MM DMSO 溶液;4E2RCat试剂;4E2RCat试剂 |
| 英文名称 | 4E2RCat |
| 英文同义词 | 4E2RCat;Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-;Eukaryotic Initiation Factor;5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid;5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid[4E2RCat;4E-2RCat,Virus Protease,4E2RCat,Inhibitor,inhibit,Autophagy,Eukaryotic Initiation Factor (eIF);4E2RCat, 10 mM in DMSO;5-(5-((3-benzyl-4-oxo-2-thiazolidinyl)methyl)furan-2-yl)-2-chlorobenzoic acid |
| CAS号 | 432499-63-3 |
| 分子式 | C22H14ClNO4S2 |
| 分子量 | 455.94 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 432499-63-3.mol |
| 结构式 |  |
432499-63-3 性质
| 沸点 | 659.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.56±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：15.5 mg/mL（34.00 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.72±0.25(Predicted) |
| 颜色 | 浅黄至黄色 |
4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5 μM。
IC50: 13.5 μM (eIF4E-eIF4G)
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100733 | 432499-63-3 4E2RCat | 432499-63-3 | 1mg | 720元 |
| 2026/06/05 | HY-100733 | 432499-63-3 4E2RCat | 432499-63-3 | 5mg | 1510元 |