4(1H)-Quinazolinone, 2-(4-nitrophenyl)-

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4(1H)-Quinazolinone, 2-(4-nitrophenyl)- manufacturers
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- Basic information
Product Name:4(1H)-Quinazolinone, 2-(4-nitrophenyl)-
Synonyms:4(1H)-Quinazolinone, 2-(4-nitrophenyl)-;2-(4-Nitrophenyl)quinazolin-4(1H)-one;4(3H)-Quinazolinone, 2-(4-nitrophenyl)-;TNKS-2-IN-1
CAS:4765-59-7
MF:C14H9N3O3
MW:267.24
EINECS:
Product Categories:
Mol File:4765-59-7.mol
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- Structure
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- Chemical Properties
Melting point >300 °C
Boiling point 479.8±47.0 °C(Predicted)
density 1.44±0.1 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka5+-.0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- Usage And Synthesis
UsesTNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].
References[1] Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27. DOI:10.1016/j.ejmech.2016.04.041
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- Preparation Products And Raw materials
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