|
|
| | GRANISETRON-D3 Basic information |
| Product Name: | GRANISETRON-D3 | | Synonyms: | Granisetron Impurity 7（Granisetron EP Impurity G）;2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID;2-Methylindazole-3-carboxylic acid;2H-Indazole-3-carboxylic acid,2-methyl-;Granisetron EP impurity G;3-Carboxy-2-methyl-2H-indazole;2-Methylindazole-3-carboxylic acid
2-Methyl-2H-indazole-3-carboxylic acid;2-Methyl-2H-indazole-3-carboxylicacid97% | | CAS: | 34252-44-3 | | MF: | C9H8N2O2 | | MW: | 176.17 | | EINECS: | 691-338-3 | | Product Categories: | Chemical Amines;Amines;Aromatics;Heterocycles | | Mol File: | 34252-44-3.mol |  |
| | GRANISETRON-D3 Chemical Properties |
| Melting point | 217-219 | | Boiling point | 417.4±18.0 °C(Predicted) | | density | 1.35 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 3.02±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | GRANISETRON-D3 Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 2-Methyl-2H-indazole-3-carboxylic acid can be used as a reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders. | | Synthesis | (Step 1) Synthesis of 2-methyl-2H-indazole-3-carboxylic acid: 2-methyl-2H-indazole-3-carboxylic acid methyl ester (1.59 g, 8.36 mmol) was dissolved in tetrahydrofuran (85 mL), followed by addition of 0.25 N sodium hydroxide solution (50 mL, 12.5 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water (appropriate amount) was added to the residue, which was then acidified with 1 N hydrochloric acid (50 mL). The precipitate precipitated was collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methyl-2H-indazole-3-carboxylic acid (1.34 g, 91% yield) as a colorless solid.1H-NMR (DMSO-d6) δ: 4.43 (s, 3H), 7.29 (m, 1H), 7.35 (m, 1H), 7.74 (dd, J = 8.1, 1.0 Hz, 1H), 7.98 (d, J = 8.5 Hz, 1H), 13.59 (broad s, 1H).MS (ESI) m/z 177 (M++1). | | References | [1] Journal of Medicinal Chemistry, 1987, vol. 30, # 9, p. 1535 - 1537
[2] Patent: EP1346982, 2003, A1
[3] Letters in Organic Chemistry, 2011, vol. 8, # 10, p. 722 - 727
[4] Patent: WO2008/61688, 2008, A1. Location in patent: Page/Page column 21 |
| | GRANISETRON-D3 Preparation Products And Raw materials |
|