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| | 3-(1-Piperidinylmethyl)phenol Basic information |
| | 3-(1-Piperidinylmethyl)phenol Chemical Properties |
| Melting point | 137-138°C | | Boiling point | 308.1±17.0 °C(Predicted) | | density | 1.097±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 9.97±0.10(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C12H17NO/c14-12-6-4-5-11(9-12)10-13-7-2-1-3-8-13/h4-6,9,14H,1-3,7-8,10H2 | | InChIKey | ORGBERFQYFWYGX-UHFFFAOYSA-N | | SMILES | C1(O)=CC=CC(CN2CCCCC2)=C1 | | CAS DataBase Reference | 73279-04-6(CAS DataBase Reference) |
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ALFA
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| | 3-(1-Piperidinylmethyl)phenol Usage And Synthesis |
| Synthesis | In a three-necked flask equipped with a stirrer, condenser tube and thermometer, add 2.4 g of m-hydroxybenzaldehyde dissolved in 40 mL of formic acid with stirring. The temperature was controlled to be below 60 °C and 4.2 g of hexahydropyridine was slowly added dropwise. After the dropwise addition was completed, the temperature was raised to 110 °C and the reaction was refluxed for 2 h (the progress of the reaction was monitored by thin layer chromatography). Upon completion of the reaction, the reaction solution was diluted with 150 mL of water and cooled to 15 °C. Decolorization was carried out by adding 0.1 g of activated carbon and filtered. The pH of the filtrate was adjusted with 12% ammonia to 8.5. allowed to stand and crystallized at 10 °C. The crystals were collected by filtration, washed with cold water and dried to give Intermediate III-1 (3-(1-piperidinylmethyl)phenol) 3.0 g as yellow crystals in 78% yield. | | References | [1] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 989 - 994
[3] ChemMedChem, 2015, vol. 10, # 1, p. 83 - 93
[4] Patent: CN103626722, 2016, B. Location in patent: Paragraph 0049-0052
[5] Synthetic Communications, 1999, vol. 29, # 1, p. 15 - 20 |
| | 3-(1-Piperidinylmethyl)phenol Preparation Products And Raw materials |
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