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| | 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride Basic information |
| | 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride Usage And Synthesis |
| Synthesis | 7-Methoxyindan-1-one oxime (2.92 g, 16 mmol) was dissolved in acetic acid (150 mL) and the hydrogenation reaction was carried out using an H-cube hydrogenation reactor under the following conditions set at a flow rate of 1 mL/min, a temperature of 80 °C, a pressure of 100 bar, and a catalyst of 10% Pd/C. Upon completion of the reaction, the solvent in the reaction mixture was removed by evaporation and the residue was dissolved in methanol, followed by the addition of 1 equiv. of hydrochloric acid in methanol. The solvent was evaporated again and the resulting residue was ground with ether to give 7-methoxy-1-aminoindan hydrochloride (2.38 g, 12 mmol, 75% yield). Electrospray mass spectrometry (ESMS) showed m/z 147 ([M + H]+). | | References | [1] Patent: WO2010/71846, 2010, A2. Location in patent: Page/Page column 160 |
| | 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride Preparation Products And Raw materials |
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