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| | WS DBCO-Biotin Basic information |
| Product Name: | WS DBCO-Biotin | | Synonyms: | WS DBCO-Biotin;DBCO-Sulfo-link-biotin,WS DBCO-Biotin;2-Propanesulfonic acid, 1-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxo-;3-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-1-[[3-(2-azatricyclo[10.4.0.0??]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxo-propyl]amino]-1-oxo-propane-2-sulfonic acid;WS Biotin DBCO ≥99% (CCT-A116) | | CAS: | 1363444-70-5 | | MF: | C31H35N5O7S2 | | MW: | 653.77 | | EINECS: | | | Product Categories: | | | Mol File: | 1363444-70-5.mol |  |
| | WS DBCO-Biotin Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | pka | 0.36±0.50(Predicted) | | form | Solid | | color | Light yellow to yellow | | Appearance | White waxy solid |
| | WS DBCO-Biotin Usage And Synthesis |
| Description | DBCO-Sulfo-Link-biotin is an anqueous soluble biotin reagent for introducing a biotin moiety to proteins and cell surfaces containing azide moiety through copper-free Click Chemistry. This biotin reagent is membrane-impermeable due to its negatively charged, water soluble sulfonate group. DBCO is commonly used for copper-free Click Chemistry reactions. | | Uses | DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Sulfo-Link-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Cleavable Linker | | References | [1] Portnoff AD, et al. An antidote approach to reduce risk and broaden utility of antibody-based therapeutics. J Biol Chem. 2017 May 19;292(20):8498-8506. |
| | WS DBCO-Biotin Preparation Products And Raw materials |
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