Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-

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Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Suppliers list
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Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Basic information
Product Name:Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
Synonyms:Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-;5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one;CX3CR1,inhibit,GPR13,CX3C chemokine receptor1,fractalkine receptor,JMS 17 2,Inhibitor,JMS172;JMS-17-2, 10 mM in DMSO
CAS:1380392-05-1
MF:C25H26ClN3O
MW:419.95
EINECS:604-604-1
Product Categories:API
Mol File:1380392-05-1.mol
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Structure
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Chemical Properties
Boiling point 603.8±55.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO:32.5(Max Conc. mg/mL);77.39(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.81(Max Conc. mM)
pka9.11±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Usage And Synthesis
UsesJMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells[1].
in vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model:SCID mice (~25g) with MDA-231 xenograft[1]
Dosage:10 mg/kg
Administration:Aministered i.p.; twice a day for three weeks
Result:Caused a dramatic reduction of tumors in both skeleton and visceral organs.
References[1] Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. DOI:10.1158/1541-7786.MCR-16-0013
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Preparation Products And Raw materials
Tag:Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-(1380392-05-1) Related Product Information
1-Triacontanol 2-Amino-4-chloro-6-methylpyrimidine Deionized water 2-Amino-1-butanol JMS 17-2 hydrochloride 5-(2-Aminoethyl)pyrrolo[1,2-a]quinoxalin-4(5h)-one