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| | 3-cyano-2,4-difluorobenzoic acid Basic information |
| | 3-cyano-2,4-difluorobenzoic acid Chemical Properties |
| Boiling point | 303.0±42.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | pka | 2.65±0.10(Predicted) |
| | 3-cyano-2,4-difluorobenzoic acid Usage And Synthesis |
| Synthesis | To a 1 L reaction vial were sequentially added 49.9 g (0.36 mol) of
2,4-difluoro-3-carboxamide benzoic acid, 31.6 g (0.40 mol) pyridine, and 376 g tetrahydrofuran (THF). Place in a low temperature bath to cool down to -5 , dropwise addition of 83.2g (0.396mol) trifluoroacetic anhydride (TFAA), about 1h dropwise. The reaction was held at -5~5 for 1 h, then warmed up to 30 and held for 3 h. At the end of the reaction, desolventized to remove THF, added 100 g of water and 180 g of ethyl acetate, partitioned, washed with water, collected the organic phase, and removed the ethyl acetate to obtain 3-cyano-2,4-difluorobenzoic acid. |
| | 3-cyano-2,4-difluorobenzoic acid Preparation Products And Raw materials |
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