| Company Name: |
Energy Chemical |
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400-0056266 |
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marketing1@energy-chemical.com |
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| | Argatroban Impurity 23 Basic information |
| Product Name: | Argatroban Impurity 23 | | Synonyms: | Argatroban-d3 (Mixture Of Diastereomers);[2H3]-Argatroban;Argatroban-d3 (hydrochloride);Argatroban-[D3] (Standard) | | CAS: | 1356847-56-7 | | MF: | C23H33D3N6O5S | | MW: | 511.652625334 | | EINECS: | | | Product Categories: | | | Mol File: | 1356847-56-7.mol |  |
| | Argatroban Impurity 23 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: soluble,DMSO: soluble,Methanol: soluble | | form | A solid |
| | Argatroban Impurity 23 Usage And Synthesis |
| Description | Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia. | | Uses | Labelled synthetic thrombin inhibitor. Antithrombotic. | | References | [1] HEE DONG PARK . Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 17: Pages 4779-4784. DOI: 10.1016/j.bmcl.2013.07.008
[2] YASUKO KATO . Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig[J]. European journal of pharmacology, 2003, 473 2: Pages 163-169. DOI: 10.1016/s0014-2999(03)01973-3 |
| | Argatroban Impurity 23 Preparation Products And Raw materials |
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