1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene

Request For Quotation
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Suppliers list
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD  
Tel: 13816107857
Email: sales@fortunechem-sh.com
Company Name: Shanghai Changyan Chem & Tech Co., Ltd.  
Tel: 021-20242659 18930833303
Email: sales@changyanchem.cn
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com

1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene manufacturers

  • NSC-636819
  • NSC-636819 pictures
  • $2520.00
  • 2026-05-11
  • CAS:1618672-71-1
  • Purity: 98.00%
  • Supply Ability: 10g
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Basic information
Product Name:1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
Synonyms:1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene;1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene;NSC 636819;Benzene, 1,5-bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitro-;KDM4A/KDM4B Inhibitor, NSC636819
CAS:1618672-71-1
MF:C22H12Cl4N2O4
MW:510.15
EINECS:
Product Categories:
Mol File:1618672-71-1.mol
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Structure
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Chemical Properties
Boiling point 625.5±55.0 °C(Predicted)
density 1.558±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Yellow to orange
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Usage And Synthesis
UsesNSC 636819 is a novel and selective KDM4A/KDM4B inhibitor that induces apoptosis in cultured prostate cancer cells.
Biological ActivityCell permeable: yes', 'Primary Target
KDM4A/B', 'Reversible: yes
in vivo

NSC636819 (C-4) (20 or 40 mg/kg; ip; 5 times a week; 4 weeks) strongly suppresses A549 tumor growth and sensitizes tumors to TRAIL-inducer ONC201 in mouse model[2].

Animal Model:A549 Lung cancer xenograft model in mice[2]
Dosage:20 mg/kg, 40 mg/kg
Administration:ip; 5 times per weeks, 27 days; with or without ONC201 (i.p.; 25mg/kg, 1 time a week).
Result:Dose-dependently inhibited the tumor growth, and sensitized tumors to TRAIL.
Induced tumor expression of TRAIL, DR5 and the level of cleaved caspase-7 and H3K9me3, whereas decreased the expression of KDM4A in xenograft tumors.
IC 50KDM4
storageStore at +4°C
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Preparation Products And Raw materials
Tag:1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene(1618672-71-1) Related Product Information
5-chloro-1,3-dimethyl-2-nitrobenzene 1-nitro-2-(2-phenylethenyl)benzene 4,5-Dichloro-2-nitrotoluene 5-Chloro-2-nitrotoluene (E)-2-Nitrostilbene Benzene, 4-chloro-2-ethenyl-1-nitro-