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| | JNJ-64619178 Basic information |
| Product Name: | JNJ-64619178 | | Synonyms: | JNJ-64619178;JNJ 64619178;JNJ64619178;CS-2829;1,2-Cyclopentanediol, 3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)-;(1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol;inhibit,JNJ 64619178,Inhibitor,JNJ64619178,Histone Methyltransferase,Onametostat,JNJ-64619178;(1S,2R,3S,5R)-3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol;Onametostat (JNJ-64619178) | | CAS: | 2086772-26-9 | | MF: | C22H23BrN6O2 | | MW: | 483.36 | | EINECS: | | | Product Categories: | | | Mol File: | 2086772-26-9.mol |  |
| | JNJ-64619178 Chemical Properties |
| Boiling point | 636.2±50.0 °C(Predicted) | | density | 1.79±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:111.0(Max Conc. mg/mL);229.64(Max Conc. mM) | | form | A solid | | pka | 13.37±0.70(Predicted) | | color | Off-white to light yellow |
| | JNJ-64619178 Usage And Synthesis |
| Uses | Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2]. | | in vivo | Oral administration of Onametostat results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer? cancer mouse xenograft models[1]. | | IC 50 | PRMT5 | | References | [1] Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.
[2] Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388. DOI:10.1248/cpb.c18-00980 |
| | JNJ-64619178 Preparation Products And Raw materials |
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