- LX2343
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- $48.00 / 5mg
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2026-02-01
- CAS:333745-53-2
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
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| | LX-2343 Basic information |
| Product Name: | LX-2343 | | Synonyms: | LX-2343;LX2343;LX-2343;LX 2343;Acetamide, N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-;2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide;Autophagy,PI3K,Amyloid-β,Inhibitor,β-Secretase,Beta-secretase,LX-2343,LX2343,inhibit,BACE,Phosphoinositide 3-kinase,β-amyloid peptide,LX 2343,Abeta;N-(Benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide;LX2343, 10 mM in DMSO;LX-2343 (LX2343) | | CAS: | 333745-53-2 | | MF: | C22H19ClN2O6S | | MW: | 474.91 | | EINECS: | | | Product Categories: | | | Mol File: | 333745-53-2.mol |  |
| | LX-2343 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:73.33(Max Conc. mg/mL);154.41(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);69.49(Max Conc. mM) | | form | A solid | | color | White to off-white |
| | LX-2343 Usage And Synthesis |
| Uses | LX-2343, is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. It has also shown activity as a non-ATP competitive PI3K inhibitor. LX2343 stimulates autophagy in its promotion of Aβ clearance. | | in vivo | APP/PS1 mice express chimeric human Swedish mutant APP and a mutant human presenilin 1 protein and are widely used as an effective animal model for AD dementia. The amelioration of memory impairment by LX2343 is evaluated t in this model using the MWM test. In 8-d training trials, the path lengths and escape latencies used to find the platform for APP/PS1 transgenic mice are remarkably longer than those for non-transgenic mice, while 10 mg/kg LX2343 administration obviously antagonizes the prolonged path lengths and escape latencies at d 7 and 8. In the probe trial assay, the LX2343-administered transgenic mice cross over the hidden location of the platform more frequently compared with the vehicle-administered transgenic mice[1]. | | IC 50 | BACE1: 11.43 μM (IC50); PI3K: 15.99 μM (IC50); Aβ; Autophagy |
| | LX-2343 Preparation Products And Raw materials |
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