Oxotremorine M
| 中文名称 | Oxotremorine M |
|---|---|
| 中文同义词 | 碘化氧化震颤素M;化合物 T12339;碘化氧化震颤素M,10 MM DMSO 溶液 |
| 英文名称 | trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide |
| 英文同义词 | trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide;Oxotremorine M (iodide);CPD3509;Oxotremorine M iodide, 10 mM in DMSO |
| CAS号 | 3854-04-4 |
| 分子式 | C11H19IN2O |
| 分子量 | 322.19 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 3854-04-4.mol |
| 结构式 |  |
Oxotremorine M 性质
| 储存条件 | Desiccate at -20°C |
|---|---|
| 溶解度 | DMSO：125 mg/mL（387.97 mM；需要超声波） |
| 形态 | 粉末 |
| 颜色 | 浅黄至黄色 |
| 水溶解性 | Soluble to 100 mM in water |
Oxotremorine M iodide 是一种有效的，非选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。
Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence.
Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC
50
of 0.22 μM. Oxotremorine M iodide has EC
50
s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g.