5-BROMOSALICYLAMIDE manufacturers
- 5-BROMOSALICYLAMIDE
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- $1.00 / 1KG
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2020-01-05
- CAS:6329-74-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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| | 5-BROMOSALICYLAMIDE Basic information |
| | 5-BROMOSALICYLAMIDE Chemical Properties |
| Melting point | 241-245 °C(lit.) | | Boiling point | 316.6±32.0 °C(Predicted) | | density | 1.759±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.79±0.18(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 28-36/37 | | WGK Germany | 3 | | RTECS | VN7000000 |
| | 5-BROMOSALICYLAMIDE Usage And Synthesis |
| Synthesis | A. Procedure for the synthesis of 5-bromo-2-hydroxybenzamide:
1. In a 100 mL round-bottom flask, 5-bromosalicylic acid (30 g, 135.5 mmol) was dissolved in n-butanol (60 mL) and concentrated sulfuric acid (95.6%, 289 μL, 5.42 mmol) was added. The unit was equipped with a Dean-Stark manifold and reflux condenser and 12 mL of n-butanol was added.
2. Reflow the reaction mixture under heat for 2 days. Upon completion of the reaction, it was cooled to room temperature and concentrated to give a light yellow oil.
3. Methanol (50 mL) was added to the above oil, followed by the slow addition of a methanol solution of ammonia (7 N, 116 mL).
4. The reaction mixture was stirred at room temperature for 2 days and the progress of the reaction was monitored by HPLC. 5.
5. After completion of the reaction, the reaction mixture was concentrated to give a white solid.
6. The crude product was washed with a small amount of ethyl acetate and hexane to give 24 g of white crystalline solid in 82% yield. | | References | [1] Patent: WO2005/95326, 2005, A2. Location in patent: Page/Page column 253
[2] Patent: US2018/64726, 2018, A1. Location in patent: Paragraph 0360; 0361
[3] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 4, p. 734 - 745
[4] Patent: US2006/14737, 2006, A1. Location in patent: Page/Page column 25 |
| | 5-BROMOSALICYLAMIDE Preparation Products And Raw materials |
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