N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine

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N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:GSK2945
CAS:1438071-12-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:GSK2945
CAS:1438071-12-5
Package:25mg;1520USD|100mg;2500USD|50mg;1980USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:GSK2945
CAS:1438071-12-5
Package:25mg;1520USD|100mg;2500USD|50mg;1980USD
Company Name: ShangHai Movin Pharmaceutical Co., Ltd.  
Tel: 13681854265
Email: info@moenpharm.com
Products Intro: Product Name:N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine
Purity:0.97 Package:10g;100g;1kg
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Email: marketing@energy-chemical.com
Products Intro: Product Name:GSK 2945
CAS:1438071-12-5
Purity:NULL Package:100mg;10mg Remarks:NULL

N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine manufacturers

  • GSK2945
  • GSK2945 pictures
  • $1520.00
  • 2026-05-11
  • CAS:1438071-12-5
  • Purity:
  • Supply Ability: 10g
  • GSK2945
  • GSK2945 pictures
  • $1520.00
  • 2025-07-17
  • CAS:1438071-12-5
  • Purity:
  • Supply Ability: 10g
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Basic information
Product Name:N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine
Synonyms:N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine;GSK-2945;GSK-2945 (GSK2945 );2-Thiophenemethanamine, N-[(4-chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-;GSK 2945 DISCONTINUED. Please see G797405
CAS:1438071-12-5
MF:C20H18Cl2N2O2S
MW:421.34
EINECS:
Product Categories:
Mol File:1438071-12-5.mol
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Structure
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Chemical Properties
Boiling point 525.0±45.0 °C(Predicted)
density 1.363±0.06 g/cm3(Predicted)
solubility Acetonitrile (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
pka5.23±0.50(Predicted)
form Solid
color Off-White to Light Beige
Stability:Hygroscopic
Safety Information
MSDS Information
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Usage And Synthesis
UsesGSK 2945 is an antagonist with high specificity for REV-ERBα, Nuclear heme receptor reverse erythroblastosis virus, which is known to regulate circadian rhythm and more specifically, regulation of cholesterol 7α-hydroxylase (CYP7A1) and bile acid synthesis.
in vivo

GSK2945 (0-10 mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice[1].

Animal Model:Male C57BL/6 mice (8-10 weeks of age)[1]
Dosage: 0 mg/kg or 10 mg/kg
Administration:Intraperitoneal injection; twice every day; for 7 days
Result:Increased hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowered plasma cholesterol in wild-type mice.
N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine Preparation Products And Raw materials
Raw materials4-CHLORO-2-METHYLBENZALDEHYDE-->4-Chlorobenzylamine
Tag:N-[(4-chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine(1438071-12-5) Related Product Information