| Company Name: |
Shanghai Beiwanta Biotechnology Co., Ltd. Gold
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| Tel: |
021-67187366 19901745723 |
| Email: |
info@bwtlab.com |
| Products Intro: |
Product Name:22(S)-hydroxy Cholesterol
CAS:22348-64-7
Purity:>=98% Package:1mg;5mg;10mg
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| | 22(S)-Hydroxycholesterol Basic information |
| Product Name: | 22(S)-Hydroxycholesterol | | Synonyms: | CHOLEST-5-ENE-3BETA,22R-DIOL;5-CHOLESTENE-3BETA,22[R]-DIOL;5-CHOLESTENE-3BETA,22[S]-DIOL;5-CHOLESTEN-3-BETA, 22(R)-DIOL;5-CHOLESTEN-3-BETA, 22(S)-DIOL;3BETA,22BETA-DIHYDROXY-5-CHOLESTENE;22[S]-Hydroxycholesterol (not deuterated);(3S,8S,9S,10R,13R,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | | CAS: | 22348-64-7 | | MF: | C27H46O2 | | MW: | 402.65 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Hydroxycholesterol | | Mol File: | 22348-64-7.mol |  |
| | 22(S)-Hydroxycholesterol Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml | | form | A crystalline solid | | InChIKey | RZPAXNJLEKLXNO-QUOSNDFLSA-N | | SMILES | O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H]([C@@H](O)CCC(C)C)C)(CC3)C)CC=C2C1)C |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 22(S)-Hydroxycholesterol Usage And Synthesis |
| Uses | The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity. | | Definition | ChEBI: An oxysterol that is the 22S-hydroxy derivative of cholesterol. | | Biological Activity | 22(S)-Hydroxycholesterol modulates the lipid and glucose metabolism by acting on liver X receptors. It has the potential to reduce lipogenesis and the accumulation of lipid in hepatocytes, myotubes and non-adipose tissue. | | in vivo | Cholest-5-ene-3,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum[2].
Pharmacokinetic Analysis in Rats[2]
| Route | Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUCt (ng·h/mL) | AUC (ng·h/mL) | T1/2 (h) | Extent of tritium exchange (%) | | i.v. | 50 | 22.4 | 0.08 | 174 | 195 | 8.1 | 2.8 | | p.o. | 50 | 7.5 | 4 | 95.2 | 104 | 6.4 | 1.2 |
| Animal Model: | Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2] | | Dosage: | 30 mg/kg/day | | Administration: | Oral gavage; 3 weeks consecutively | | Result: | Decreased body weight gain significantly after 1 week treatment.
Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment. |
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| | 22(S)-Hydroxycholesterol Preparation Products And Raw materials |
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