- 4-(2-Pyridinyl)benzaldehyde
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- $15.00 / 1KG
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2021-07-13
- CAS:127406-56-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 4-(2-Pyridinyl)benzaldehyde Basic information |
| | 4-(2-Pyridinyl)benzaldehyde Chemical Properties |
| Melting point | 50-52 °C(lit.) | | Boiling point | 340.4±25.0 °C(Predicted) | | density | 1.147±0.06 g/cm3(Predicted) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in Chloroform | | pka | 3.97±0.25(Predicted) | | form | Solid | | color | White to Off-White Waxy | | InChI | 1S/C12H9NO/c14-9-10-4-6-11(7-5-10)12-3-1-2-8-13-12/h1-9H | | InChIKey | NMLYGLCBSFKJFI-UHFFFAOYSA-N | | SMILES | [H]C(=O)c1ccc(cc1)-c2ccccn2 | | CAS DataBase Reference | 127406-56-8(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37-36/37/39-22 | | WGK Germany | 3 | | Hazard Note | Harmful | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-(2-Pyridinyl)benzaldehyde Usage And Synthesis |
| Chemical Properties | White Waxy Solid | | Uses | Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity | | General Description | 4-(2-Pyridyl)benzaldehyde is a p-substituted benzaldehyde. | | Synthesis | General procedure for the synthesis of 4-(2-pyridyl)-benzaldehyde from 2-bromopyridine and 4-formylphenylboronic acid: 1.1 equiv. of the brominated derivatives (13- of 2-bromopyridine and 14- of 1-bromo-4-nitrobenzene) of 4-formylphenylboronic acid, Pd(OAc)2 (2 mol%), and PPh3 (4 mol%) were added to a Schlenk flask. Methanol/THF (1:1, 2 mL/mmol) and 2 eq. of KOH were added under an inert atmosphere. the reaction system was stirred at 60 °C for 24 h. The reaction system was then purified by column chromatography. The target compounds were purified by column chromatography (eluent: cyclohexane/EtOAc, 9:1) to afford the products 13a and 14a in 80% and 75% yields, respectively. | | References | [1] European Journal of Organic Chemistry, 2008, # 12, p. 2049 - 2055
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 47, p. 14103 - 14107
[3] Angew. Chem., 2015, vol. 127, # 47, p. 14309 - 14313,5
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 39, p. 6806 - 6813
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 27, p. 5901 - 5905 |
| | 4-(2-Pyridinyl)benzaldehyde Preparation Products And Raw materials |
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