|
|
| | 1-Hydroxyethylethoxypiperazine Basic information |
| | 1-Hydroxyethylethoxypiperazine Chemical Properties |
| Boiling point | 112-114 °C0.25 mm Hg(lit.) | | density | 1.061 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.497(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | | pka | 14.41±0.10(Predicted) | | form | Liquid | | color | Clear colorless to yellow-brownish | | Specific Gravity | 1.061 | | InChI | InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2 | | InChIKey | FLNQAPQQAZVRDA-UHFFFAOYSA-N | | SMILES | C(O)COCCN1CCNCC1 | | CAS DataBase Reference | 13349-82-1(CAS DataBase Reference) | | NIST Chemistry Reference | 1-(2-(2-Hydroxyethoxy)ethyl)piperazine(13349-82-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29335990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-Hydroxyethylethoxypiperazine Usage And Synthesis |
| Chemical Properties | Yellow-Brown Oil | | Uses | 1-[2-(2-Hydroxyethoxy)ethyl]piperazine may be used in chemical synthesis. | | Uses | Quetiapine intermediate | | Definition | ChEBI: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine is a N-alkylpiperazine. | | Synthesis | The general procedure for the synthesis of 1-[2-(2-hydroxyethoxy)ethyl]piperazine from the compound (CAS:166388-52-9) was as follows: 54.2 g of compound 3 was dissolved in 300 mL of dichloromethane, followed by the addition of 26 g of trifluoroacetic acid. The reaction mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, 1 N NaOH aqueous solution was added and stirring was continued for 30 minutes. The reaction mixture was left to partition and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 32.6 g of a colorless liquid product, i.e., 1-[2-(2-hydroxyethoxy)ethyl]piperazine. The yield was 95%. | | References | [1] Patent: CN107663183, 2018, A. Location in patent: Paragraph 0022; 0023; 0024 |
| | 1-Hydroxyethylethoxypiperazine Preparation Products And Raw materials |
|