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| | 1-N-CBZ-3-HYDROXY-PIPERIDINE Basic information | | Uses |
| Product Name: | 1-N-CBZ-3-HYDROXY-PIPERIDINE | | Synonyms: | BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;BUTTPARK 99\04-58;3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-N-CBZ-3-HYDROXY-PIPERIDINE;1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE;1-Cbz-3-hydroxy-piperidine;1-Piperidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester;N-Cbz-3-hydroxypiperidine | | CAS: | 95798-22-4 | | MF: | C13H17NO3 | | MW: | 235.28 | | EINECS: | | | Product Categories: | | | Mol File: | 95798-22-4.mol |  |
| | 1-N-CBZ-3-HYDROXY-PIPERIDINE Chemical Properties |
| Boiling point | 196 °C | | density | 1.220±0.06 g/cm3(Predicted) | | storage temp. | Store at room temperature | | pka | 14.72±0.20(Predicted) | | Appearance | Light yellow to yellow Liquid |
| | 1-N-CBZ-3-HYDROXY-PIPERIDINE Usage And Synthesis |
| Uses | Benzyl 3-hydroxytetrahydropyridinecarboxylate is a carboxylic acid ester organic compound that can be used as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of N-Benzyloxycarbonyl-3-hydroxypiperidine from 3-hydroxypiperidine hydrochloride and benzyl chloroformate: Na2CO3 (23.10 g, 218 mmol) was added to a solution of THF/H2O (50 mL/50 mL) containing 3-hydroxypiperidine hydrochloride (10.00 g, 73 mmol). Benzyl chloroformate (14.90 g, 87 mmol) was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. After the reaction was completed, the mixture was extracted with EtOAc (100 mL x 3). The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography with EtOAc/petroleum ether (1/100~1/4, v/v) as eluent to afford N-benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 96%) as a colorless oil. detected by TLC: Rf = 0.65 (silica gel plate, EtOAc/petroleum ether = 1/1, v/v). | | References | [1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 15 |
| | 1-N-CBZ-3-HYDROXY-PIPERIDINE Preparation Products And Raw materials |
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