2-(4-METHYLPIPERAZINO)BENZALDEHYDE manufacturers
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| | 2-(4-METHYLPIPERAZINO)BENZALDEHYDE Basic information |
| Product Name: | 2-(4-METHYLPIPERAZINO)BENZALDEHYDE | | Synonyms: | BUTTPARK 33\06-51;2-(4-METHYLPIPERAZIN-1-YL)BENZALDEHYDE;2-(4-METHYLPIPERAZINO)BENZALDEHYDE;2-(4-Methylpiperazino)benzadehyde;2-(4-methyl-1-piperazin-4-iumyl)benzaldehyde;Benzaldehyde, 2-(4-methyl-1-piperazinyl)-;2-(4-Methyl-1-piperazinyl)benzaldehyde | | CAS: | 85803-62-9 | | MF: | C12H16N2O | | MW: | 204.27 | | EINECS: | | | Product Categories: | Amino Acid Derivatives | | Mol File: | 85803-62-9.mol |  |
| | 2-(4-METHYLPIPERAZINO)BENZALDEHYDE Chemical Properties |
| Melting point | 44 °C | | Boiling point | 110 | | density | 1.107±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 7.69±0.42(Predicted) | | Appearance | Colorless to light yellow Liquid | | CAS DataBase Reference | 85803-62-9(CAS DataBase Reference) |
| | 2-(4-METHYLPIPERAZINO)BENZALDEHYDE Usage And Synthesis |
| Synthesis | General procedure: 2-fluorobenzaldehyde (20.0 mL, 189.9 mmol), 1-methylpiperazine (33.0 mL, 297.7 mmol) and potassium carbonate (40.0 g, 289.4 mmol) were dissolved in water (200 mL) and heated to reflux. After the reaction was completed, it was cooled to room temperature and the reaction mixture was extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the target product 2-(4-methylpiperazine)benzaldehyde (PP57, 38.6 g, 100%) as an orange oil. Its NMR hydrogen spectrum (CDCl3) data were as follows: δ 10.10 (s, 1H), 7.77 (dd, J = 7.9, 1.7 Hz, 1H), 7.51-7.48 (m, 1H), 7.10-7.06 (m, 2H), 3.11 (t, J = 4.6 Hz, 4H), 2.63 (br s, 4H), 2.36 (s, 3H) . | | References | [1] Patent: WO2006/48727, 2006, A1. Location in patent: Page/Page column 83
[2] Patent: US2003/87914, 2003, A1
[3] Russian Chemical Bulletin, 2004, vol. 53, # 6, p. 1240 - 1247
[4] Chemical Communications, 2017, vol. 53, # 75, p. 10448 - 10451
[5] Synthesis, 1987, # 7, p. 641 - 645 |
| | 2-(4-METHYLPIPERAZINO)BENZALDEHYDE Preparation Products And Raw materials |
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