- Isopropylparaben
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- $0.00 / 1removed
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2026-04-22
- CAS:4191-73-5
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
- Isopropylparaben
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- $10.00 / 1KG
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2026-03-20
- CAS:4191-73-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Isopropylparaben Basic information |
| Product Name: | Isopropylparaben | | Synonyms: | 1-methylethyl4-hydroxybenzoate;4-hydroxy-benzoicaci1-methylethylester;Benzoic acid, p-hydroxy-, isopropyl ester;p-hydroxy-benzoicaciisopropylester;p-Oxybenzoesaureisopropylester;ISOPROPYL 4-HYDROXYBENZOATE;ISOPROPYLHYDROXYBENZOATE;BENZOIC ACID, 4-HYDROXY-, 1-METHYLETHYL ESTER | | CAS: | 4191-73-5 | | MF: | C10H12O3 | | MW: | 180.2 | | EINECS: | 224-069-3 | | Product Categories: | Cosmetics;Aromatics;Aromatic Esters | | Mol File: | 4191-73-5.mol |  |
| | Isopropylparaben Chemical Properties |
| Melting point | 84-86°C | | Boiling point | 160 °C / 5mmHg | | density | 1.132±0.06 g/cm3(Predicted) | | vapor pressure | 0.155Pa at 25℃ | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in Chloroform, Ethyl Acetate. | | pka | 8.40±0.15(Predicted) | | form | powder to lump | | color | White | | Water Solubility | 1.204g/L | | BRN | 2641564 | | Cosmetics Ingredients Functions | PRESERVATIVE | | Cosmetic Ingredient Review (CIR) | Isopropylparaben (4191-73-5) | | LogP | 2.316 at 25℃ | | CAS DataBase Reference | 4191-73-5(CAS DataBase Reference) | | NIST Chemistry Reference | Isopropyl-4-hydroxybenzoate(4191-73-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RTECS | DH2250000 | | HazardClass | IRRITANT | | HS Code | 2918290090 |
| Provider | Language |
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ALFA
| English |
| | Isopropylparaben Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | It is used as a preservative in cosmetics. | | Uses | An antimicrobial | | Definition | ChEBI: Isopropylparaben is a 4-hydroxybenzoate ester. | | Contact allergens | This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid
and an alcohol. They are largely used as biocides in
cosmetics and toiletries, medicaments, or food. They
have synergistic power with other biocides. Parabens
can induce allergic contact dermatitis, mainly in
chronic dermatitis and wounded skin. | | Synthesis | GENERAL METHOD: Thionyl chloride (1.16 g, 1.5 eq.) was slowly added dropwise to a solution of p-hydroxybenzoic acid (1.0 g, 1.0 eq.) dissolved in isopropanol (15 ml) at 0 °C. The reaction mixture was heated to reflux under nitrogen protection until thin layer chromatography (TLC) monitoring showed complete consumption of p-hydroxybenzoic acid. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate/hexane to give the final isopropyl 4-hydroxybenzoate. | | References | [1] Synthesis, 2003, # 16, p. 2479 - 2482
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2004, vol. 179, # 6, p. 1187 - 1191
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 6, p. 1564 - 1569
[4] Journal of the Society of Chemical Industry, London, 1947, vol. 66, p. 175
[5] Archiv der Pharmazie (Weinheim, Germany), 1938, vol. 276, p. 154,162 |
| | Isopropylparaben Preparation Products And Raw materials |
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