- 6-Chloromethyluracil
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- $0.00 / 1kg
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2025-08-29
- CAS:18592-13-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1
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| | 6-(Chloromethyl)uracil Basic information |
| Product Name: | 6-(Chloromethyl)uracil | | Synonyms: | 6-Chloromethyl-1H-pyrimidine-2,4-dione;6-(Chloromethyl)uracil,98%;6-(chloroMethyl)-1,2,3,4-tetrahydropyriMidine-2,4-dione;2,4(1H,3H)-PyriMidinedione, 6-(chloroMethyl)-;Uracil, 6-(chloroMethyl)- (8CI);6-ChloroMethyluracil, 98.0%(T);3h)-pyrimidinedione,6-(chloromethyl)-4(1h;TIMTEC-BB SBB003961 | | CAS: | 18592-13-7 | | MF: | C5H5ClN2O2 | | MW: | 160.56 | | EINECS: | 242-431-9 | | Product Categories: | Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;18592-13-7 | | Mol File: | 18592-13-7.mol |  |
| | 6-(Chloromethyl)uracil Chemical Properties |
| Melting point | 257 °C (dec.)(lit.) | | density | 1.393±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | almost transparency in N,N-DMF | | pka | 7.91±0.10(Predicted) | | form | powder to crystal | | color | White to Light yellow | | InChI | InChI=1S/C5H5ClN2O2/c6-2-3-1-4(9)8-5(10)7-3/h1H,2H2,(H2,7,8,9,10) | | InChIKey | VCFXBAPEXBTNEA-UHFFFAOYSA-N | | SMILES | C1(=O)NC(CCl)=CC(=O)N1 | | CAS DataBase Reference | 18592-13-7(CAS DataBase Reference) | | EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)- (18592-13-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 6-(Chloromethyl)uracil Usage And Synthesis |
| Uses | 6-(Chloromethyl)uracil is an alkali-resistant protein adsorbent, suitable for medical procedures. it is also used in the synthesis of chlorophenyl hydroxypiperidine analogs having anti-amylatic activity. | | Synthesis | In a 250 mL three-necked flask, 6-(hydroxymethyl)uracil (11.5 g, 0.081 mol) was added, followed by 115 mL of dichloromethane, thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N,N-dimethylformamide in sequence. The reaction mixture was heated to reflux temperature and stirred continuously for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration, washed with dichloromethane and dried to give 6-(chloromethyl)uracil (11.8 g, 90.8% yield). | | References | [1] European Journal of Medicinal Chemistry, 2013, vol. 70, p. 400 - 410
[2] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 367 - 373
[3] Patent: CN106831607, 2017, A. Location in patent: Paragraph 0049
[4] Patent: CN106892902, 2017, A. Location in patent: Paragraph 0099; 0100; 0101; 0102 |
| | 6-(Chloromethyl)uracil Preparation Products And Raw materials |
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