- 4-Fluoroacetophenone
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- $10.00 / 1ASSAYS
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2026-05-09
- CAS:403-42-9
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
- 4-Fluoroacetophenone
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- $3.00 / 200kg
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2026-05-09
- CAS:403-42-9
- Min. Order: 1kg
- Purity: 99.5%
- Supply Ability: 500mt
- 4'-Fluoroacetophenone
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- $0.00 / 1kg
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2026-04-27
- CAS:403-42-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 100tons
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| | 4-Fluoroacetophenone Basic information |
| | 4-Fluoroacetophenone Chemical Properties |
| Melting point | 4 °C | | Boiling point | 77-78 °C10 mm Hg(lit.) | | density | 1.143 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.511(lit.) | | Fp | 160 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate | | form | Liquid | | color | Clear colorless to slightly yellow | | Specific Gravity | 1.138 | | BRN | 386013 | | InChI | 1S/C8H7FO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,1H3 | | InChIKey | ZDPAWHACYDRYIW-UHFFFAOYSA-N | | SMILES | CC(=O)c1ccc(F)cc1 | | CAS DataBase Reference | 403-42-9(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanone, 1-(4-fluorophenyl)-(403-42-9) | | EPA Substance Registry System | 4'-Fluoroacetophenone (403-42-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-23 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29147090 | | Storage Class | 10 - Combustible liquids |
| | 4-Fluoroacetophenone Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid | | Uses | 4’Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products. | | Uses | 4-Fluoroacetophenone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. | | Uses | 4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products. | | Reactions | 4-Fluoroacetophenone is a versatile aromatic ketone, it can undergo nucleophilic substitution and acylation reactions. | | Hazard |
4-Fluoroacetophenone is a combustible liquid, it causes skin irritation and serious eye irritation.
| | Synthesis |
General procedure: Oximes (1.0 mmol), Amberlyst-15 (0.02 g), FPA53-NO2(0.02 g), and solvent (1.5 mL) were introduced into a 25-cm-high, 90-mL autoclave with a glass tube inside equipped with magnetic stirrer (Scheme 2). Then the autoclave was charged with oxygen to 0.1 MPa. The reaction mixture was stirred at desirable temperature for special time. Progress of the reaction was monitored by thin-layer chromatography (TLC) or gas chromatography (GC). After the reaction, the resin (Amberlyst-15 and FPA53-NO2) was separated from the reaction mixture by filtration and extracted with 3 mL CH3CN (2 1.5 ml). The solvent was removed under reduced pressure. The residue was further purified by column chromatography on silica gel (300 mesh) with hexane/ethyl acetate to give the 4-Fluoroacetophenone.
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| | 4-Fluoroacetophenone Preparation Products And Raw materials |
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