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| | 1,2,2,6,6-Pentamethyl-4-piperidinol Basic information |
| Product Name: | 1,2,2,6,6-Pentamethyl-4-piperidinol | | Synonyms: | 1,2,2,6,6-pentamethyl-4-piperidino;1,2,2,6,6-PENTAMETHYL-4-PIPERIDINOL;1,2,2,6,6-PENTAMETHYL-4-HYDROXYPIPERIDINE;METHYL-TAA-OL;N-METHYL-2,2,6,6-TETRAMETHYL-4-PIPERIDINOL;N-METHYL-TRIACETONAMINO ALCOHOL;N-Methyltriacetoneaminoalcohol;1,2,2,6,6-PENTAMETHYL-4-PIPERIDINOL 99+% | | CAS: | 2403-89-6 | | MF: | C10H21NO | | MW: | 171.28 | | EINECS: | 219-292-8 | | Product Categories: | Piperidines;Building Blocks;C10;Chemical Synthesis;Heterocyclic Building Blocks;Industrial/Fine Chemicals;API intermediates | | Mol File: | 2403-89-6.mol |  |
| | 1,2,2,6,6-Pentamethyl-4-piperidinol Chemical Properties |
| Melting point | 72-76 °C | | Boiling point | 238 °C | | density | 0.967 | | vapor pressure | 0.845Pa at 25℃ | | refractive index | 1.4621 (estimate) | | Fp | 118 °C | | storage temp. | Sealed in dry,Room Temperature | | form | Flakes | | pka | 14.93±0.60(Predicted) | | color | Light yellow | | Water Solubility | 4.8 g/100 mL (20 ºc) | | BRN | 1498 | | InChI | 1S/C10H21NO/c1-9(2)6-8(12)7-10(3,4)11(9)5/h8,12H,6-7H2,1-5H3 | | InChIKey | NWHNXXMYEICZAT-UHFFFAOYSA-N | | SMILES | CN1C(C)(C)CC(O)CC1(C)C | | LogP | 1.15 at 25℃ | | CAS DataBase Reference | 2403-89-6(CAS DataBase Reference) | | EPA Substance Registry System | 4-Piperidinol, 1,2,2,6,6-pentamethyl- (2403-89-6) |
| Hazard Codes | Xi,C,N,Xn | | Risk Statements | 43-34-22-51/53 | | Safety Statements | 36/37-45-36/37/39-26-61 | | RIDADR | UN3261 - class 8 - PG 1 - EHS - Corrosive solid, acidic, organic, n.o.s., HI: all | | WGK Germany | 2 | | TSCA | TSCA listed | | HS Code | 29333990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 2
Skin Corr. 1A
Skin Sens. 1 |
| | 1,2,2,6,6-Pentamethyl-4-piperidinol Usage And Synthesis |
| Chemical Properties | LIGHT YELLOW FLAKES | | Uses | Reactant for: Synthesis of photostable blue emitting naphthalimides1 Synthesis of blue fluorescent naphthalimide pH chemosensors2 Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen3 Synthesis of spiropyrans and spirooxazines4 Amine photoredox reactions5 | | Uses | 1,2,2,6,6-Pentamethyl-4-piperidinol is used in the synthesis of PDGFR kinase inhibitors. Also, it can be applied to the preparation of a new diol-functionalized amine light stabilizer. | | Uses | Reactant for:
Synthesis of photostable blue emitting naphthalimides
Synthesis of blue fluorescent naphthalimide pH chemosensors
Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen
Synthesis of spiropyrans and spirooxazines
Amine photoredox reactions | | Flammability and Explosibility | Non flammable | | Synthesis | 1,2,2,6,6-pentamethylpiperidinol was synthesized by reductive methylation reaction using 2,2,6,6-tetramethylpiperidinol, paraformaldehyde and formic acid as the raw materials and water as the solvent, and the structure of the product was characterized by nuclear magnetic resonance (NMR) hydrogen spectroscopy, carbon spectroscopy and infrared spectroscopy. The results of one-way and orthogonal experiments showed that the molar ratio of raw materials had the greatest influence on the reductive methylation reaction, followed by the reaction temperature and finally the reaction time. The suitable conditions for this reductive methylation reaction were: n (tetramethylpiperidinol): n (paraformaldehyde): n (formic acid) = 1:1.05:1.05, reaction temperature of 80 C, reaction time of 2.5 h, and the solvent water could be applied three times. Under this optimized condition, the average yield of pentamethylpiperidinol was 97.9% and the purity was 99.6%. | | Toxics Screening Level | The initial threshold screening level (ITSL) for 1,2,2,6,6-pentamethyl-4-piperidinol is
0.1 μg/m3 based on annual averaging time. |
| | 1,2,2,6,6-Pentamethyl-4-piperidinol Preparation Products And Raw materials |
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