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- 5-Azacytosine
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-
2026-09-11
- CAS:931-86-2
- Min. Order: 1kg
- Purity: 98%min HPLC
- Supply Ability: 500 KG
- 5-azacytosine
-
- $99.00
-
2026-09-04
- CAS:931-86-2
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20Ton
- 5-Azacytosine
-
- $2.00
-
2026-08-25
- CAS:931-86-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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| | 5-Azacytosine Basic information |
| | 5-Azacytosine Chemical Properties |
| Melting point | >300 °C (lit.) | | Boiling point | 209.98°C (rough estimate) | | density | 1.86 | | refractive index | 1.8010 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated) | | form | Solid | | pka | 7.61±0.10(Predicted) | | color | White to Off-White | | BRN | 116378 | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C3H4N4O/c4-2-5-1-6-3(8)7-2/h1H,(H3,4,5,6,7,8) | | InChIKey | MFEFTTYGMZOIKO-UHFFFAOYSA-N | | SMILES | N1C(N)=NC=NC1=O | | CAS DataBase Reference | 931-86-2(CAS DataBase Reference) |
| | 5-Azacytosine Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Uses | Reactant for:
- Enzymic synthesis of nucleoside analogs using immobilized 2′-deoxyribosyltransferase from Lactobacillus reuteri
- Reactions with oxide radical ion
- Potential antitumor and antiproliferative agent against human leukemia cells
| | Uses | 5-Azacytosine can inhibits the growth of Escherichia coli and used as the most effective cytosine mimics for the design of novel antiviral and anti-tumor drug candidates. | | Definition | ChEBI: A monoamino-1,3,5-triazine that is cytosine in which the aromatic CH at position 5 is replaced by a nitrogen. | | Synthesis | (1) Add 1.5Kg of anhydrous formic acid (99.5% purity), 2.5kg of dicyandiamide and 0.005Kg of p-toluenesulfonic acid catalyst to a 10L autoclave. Under the condition of sealing and stirring, the reaction system was slowly warmed up to 110°C and the reaction pressure was maintained. After the reaction was completed, the temperature was slowly cooled down to room temperature to obtain a white solid product. (2) The resulting white solid was transferred to a 50L glass reactor and 10L of dilute hydrochloric acid solution with a mass concentration of 5% was added. Heating was refluxed for 30 minutes until the solution was clarified. Subsequently, the mixture was filtered through a cartridge into a crystallizer. A 30% ammonia solution was added to the crystallizer and the pH was adjusted to 6. White crystals were precipitated. After centrifugation and drying in a hot air oven, 2.8-5 kg of 6-amino-1,3,5-triazin-2(1H)-one (85% yield as dicyandiamide) was finally obtained. | | References | [1] Patent: CN105837524, 2016, A. Location in patent: Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048-0079
[2] Chemische Berichte, 1954, vol. 87, p. 19,23
[3] Archiv der Pharmazie (Weinheim, Germany), 1955, vol. 288, p. 139
[4] Patent: CN104402836, 2016, B. Location in patent: Paragraph 0025; 0026; 0027; 0028 |
| | 5-Azacytosine Preparation Products And Raw materials |
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