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| | 3-FLUORO-4-BROMO-ACETOPHENONE Basic information |
| Product Name: | 3-FLUORO-4-BROMO-ACETOPHENONE | | Synonyms: | 3-FLUORO-4-BROMO-ACETOPHENONE;4-BROMO-3-FLUORO-ACETOPHENONE;6-acetyl-3-bromo-2-fluoro-1-cyclohexa-2,4-dienone;1-(4-BroMo-3-fluorophenyl)ethanone;1-(4-broMo-3-fluorophenyl)ethan-1-one;Ethanone, 1-(4-broMo-3-fluorophenyl)-;3-Fluoro-4-bromo-caetophenone;4-Bromo-3-fluoroacetophenone,96% | | CAS: | 304445-49-6 | | MF: | C8H6BrFO | | MW: | 217.04 | | EINECS: | | | Product Categories: | | | Mol File: | 304445-49-6.mol |  |
| | 3-FLUORO-4-BROMO-ACETOPHENONE Chemical Properties |
| Boiling point | 263.3℃ | | density | 1.535 | | Fp | 113.0℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid | | Appearance | Off-white to yellow Solid |
| | 3-FLUORO-4-BROMO-ACETOPHENONE Usage And Synthesis |
| Synthesis | A tetrahydrofuran solution of 3.00 M methylmagnesium chloride (125 mL, 0.38 mol) was added slowly and dropwise to a tetrahydrofuran (500 mL) solution of 4-bromo-3-fluoro-N-methoxy-N-methylbenzamide (58.5 g, 0.223 mol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with pre-cooled saturated ammonium chloride solution (150 mL). The organic layer was separated and the remaining aqueous phase was extracted with ethyl acetate (3 x 50 mL). All organic phases were combined, washed with saturated brine, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude product 3-fluoro-4-bromoacetophenone (48.4 g, 99% yield), which could be used in the subsequent reaction without further purification. | | References | [1] Patent: US2008/39457, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2008/64157, 2008, A1. Location in patent: Page/Page column 42-43
[3] Patent: US2009/291956, 2009, A1. Location in patent: Page/Page column 19
[4] Patent: US2011/212967, 2011, A1. Location in patent: Page/Page column 8
[5] Patent: WO2012/48421, 2012, A1. Location in patent: Page/Page column 24 |
| | 3-FLUORO-4-BROMO-ACETOPHENONE Preparation Products And Raw materials |
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