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| | C2 L-erythro Ceramide (d18:1/2:0) Basic information |
| Product Name: | C2 L-erythro Ceramide (d18:1/2:0) | | Synonyms: | C2 L-erythro Ceramide (d18:1/2:0);Acetamide, N-[(1R,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-;Acetyl-L-erythro-sphingosine;N-[(1R,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide | | CAS: | 150338-90-2 | | MF: | C20H39NO3 | | MW: | 341.53 | | EINECS: | | | Product Categories: | | | Mol File: | 150338-90-2.mol |  |
| | C2 L-erythro Ceramide (d18:1/2:0) Chemical Properties |
| Boiling point | 532.4±50.0 °C(Predicted) | | density | 0.964±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: soluble; DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 13.50±0.20(Predicted) |
| | C2 L-erythro Ceramide (d18:1/2:0) Usage And Synthesis |
| Description | C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is >50% less than that stimulated by C2 ceramide . C2 L-erythro Ceramide also induces cell cycle arrest in the G0\G1 phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells. [Matreya, LLC. Catalog No. 1847] | | Uses | C2 L-Erythro ceramide (d18:1/2:0) is a cell-permeable sphingolipid. C2 L-Erythro ceramide (d18:1/2:0) induces cell cycle arrest in the G0/G1 phase and inhibits cell growth[1][2]. | | References | [1] Baek MY, et al. Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells. Arch Pharm Res. 2001 Apr;24(2):144-9. DOI:10.1007/BF02976482
[2] Bielawska A, et al. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993;268(35):26226-26232. PMID:8253743 |
| | C2 L-erythro Ceramide (d18:1/2:0) Preparation Products And Raw materials |
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