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BOC Sciences
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1-631-485-4226; 16314854226 |
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| Products Intro: |
Product Name:IMP-1088
CAS:2059148-82-0
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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IMP-1088 manufacturers
- IMP-1088
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- $147.00
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2026-07-15
- CAS:2059148-82-0
- Purity: 99.18%
- Supply Ability: 10g
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| | IMP-1088 Basic information |
| Product Name: | IMP-1088 | | Synonyms: | IMP-1088;IMP-1088;IMP1088;IMP 1088;1H-Indazole-3-methanamine, 5-[3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl]-N,N,1-trimethyl-;1-(5-(3,4-difluoro-2-(2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)ethoxy)phenyl)-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine;(5-{3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)methyl]dimethylamine;IMP-1088, 10 mM in DMSO;1-[5-[3,4-difluoro-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methylindazol-3-yl]-N,N-dimethylmethanamine | | CAS: | 2059148-82-0 | | MF: | C25H29F2N5O | | MW: | 453.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2059148-82-0.mol |  |
| | IMP-1088 Chemical Properties |
| Boiling point | 566.9±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Methyl Acetate: 10 mg/ml | | pka | 7.73±0.28(Predicted) | | form | Solid | | color | Colorless to light yellow |
| | IMP-1088 Usage And Synthesis |
| Uses | IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1]. | | References | [1] Aurélie Mousnier, et al. Fragment-derived Inhibitors of Human N-myristoyltransferase Block Capsid Assembly and Replication of the Common Cold Virus. Nat Chem. 2018 Jun;10(6):599-606. DOI:10.1038/s41557-018-0039-2 |
| | IMP-1088 Preparation Products And Raw materials |
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