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| | Eicosapentaenoic Acid Alkyne Basic information |
| | Eicosapentaenoic Acid Alkyne Chemical Properties |
| solubility | 0.15M Tris-HCl pH 8.5: >1 mg/ml
DMF: >100 mg/ml
DMSO: >100 mg/ml
Ethanol: >100 mg/mlPBS (pH 7.2): <100 µg/ml |
| | Eicosapentaenoic Acid Alkyne Usage And Synthesis |
| Description | Eicosapentaenoic acid (EPA; Item No. 90110) is an ω-3 fatty acid abundantly available in marine organisms that has been shown to offer anti-inflammatory and cardiovascular benefits.1,2 EPA alkyne is a form of EPA with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions to tag EPA with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.3,4 Because the alkyne group is at the ω-terminus, this compound can be used to easily tag metabolites and derivatives.WARNING This product is not for human or veterinary use. | | References | [1] N R YERRAM A A S S A Moore. Eicosapentaenoic acid metabolism in brain microvessel endothelium: effect on prostaglandin formation.[J]. Journal of Lipid Research, 1989, 30 11: 1747-1757.
[2] H. TAKEUCHI. Dietary Effects of n-3 Eicosapentaenoic Acid on Essential Fatty Acid-deficiency Symptoms of Rats[J]. Agricultural and biological chemistry, 1989, 22 1: 3225-3232. DOI: 10.1271/bbb1961.53.3225
[3] HARTMUTH C KOLB K. B S. The growing impact of click chemistry on drug discovery[J]. Drug Discovery Today, 2003, 8 24: Pages 1128-1137. DOI: 10.1016/s1359-6446(03)02933-7
[4] JEAN-FRANÇOIS LUTZ Zoya Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry[J]. Advanced drug delivery reviews, 2008, 60 9: Pages 958-970. DOI: 10.1016/j.addr.2008.02.004 |
| | Eicosapentaenoic Acid Alkyne Preparation Products And Raw materials |
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