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| | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Basic information |
| Product Name: | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE | | Synonyms: | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE;5,8,11,14-Eicosatetraenoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z)-;SAPE;5Z,8Z,11Z,14Z-eicosatetraenoicacid,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethylester;2-Ammonioethyl ((R)-2-(((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl)oxy)-3-(stearoyloxy)propyl) phosphate | | CAS: | 61216-62-4 | | MF: | C43H78NO8P | | MW: | 768.07 | | EINECS: | | | Product Categories: | | | Mol File: | 61216-62-4.mol |  |
| | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Chemical Properties |
| Boiling point | 776.1±70.0 °C(Predicted) | | density | 1.013±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Ethanol:PBS (pH 7.2)(1:2): 1 mg/ml; Methanol: 10 mg/ml | | pka | 1.17±0.50(Predicted) | | form | Liquid | | color | Colorless to light yellow | | InChIKey | ANRKEHNWXKCXDB-BHFWLYLHSA-N | | SMILES | [H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O |
| WGK Germany | WGK 3 | | Storage Class | 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | | Hazard Classifications | Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 3
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1
STOT SE 3 |
| | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Usage And Synthesis |
| Description | 1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE is a naturally-occurring phospholipid that is formed via the phosphatidylserine decarboxylation pathway in mammalian cells. It has been used in the generation of giant unilamellar vesicles for use in the study of biological membranes. | | Uses | 18:0-20:4 PE maybe used in the preparation of liposomes. | | Uses | SAPE is used in the mRNA combination therapy for treatment of cancer. | | Definition | ChEBI: 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine zwitterion is a phosphatidylethanolamine 38:4 zwitterion obtained by transfer of a proton from the phosphate to the primary amino group of 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine; major species at pH 7.3. It is a phosphatidylethanolamine 38:4 zwitterion and a 1-stearoyl-2-acyl-sn-glycero-3-phosphoethanolamine zwitterion. It is a tautomer of a 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine. | | References | [1] ONNO B BLEIJERVELD. The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.[J]. The Journal of Biological Chemistry, 2007, 282 39: 28362-28372. DOI: 10.1074/jbc.m703786200
[2] BILLERIT C, JEFFRIES G D M, ORWAR O, et al. Formation of giant unilamellar vesicles from spin-coated lipid films by localized IR heating[J]. Soft Matter, 2012, 42: 10823-10826. DOI: 10.1039/c2sm26394g |
| | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Preparation Products And Raw materials |
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