AMG-333 manufacturers
- AMG 333
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- $40.00 / 5mg
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2026-05-11
- CAS:1416799-28-4
- Min. Order:
- Purity: 99.95%
- Supply Ability: 10g
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| | AMG-333 Basic information |
| Product Name: | AMG-333 | | Synonyms: | AMG-333;AMG333;AMG 333;3-Pyridinecarboxylic acid, 6-[[[(S)-(3-fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-;Inhibitor,AMG333,TRP Channel,inhibit,Transient receptor potential channels,AMG 333;(S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic acid;AMG 333, 10 mM in DMSO;AMG-333 ，S6638 | | CAS: | 1416799-28-4 | | MF: | C20H12F5N3O4 | | MW: | 453.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1416799-28-4.mol |  |
| | AMG-333 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 125 mg/mL (275.74 mM) | | form | A solid | | color | White to off-white |
| | AMG-333 Usage And Synthesis |
| Uses | AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. | | in vivo | AMG 333 (0.6-3 mg/kg, p.o., single dose) dose-dependently inhibits wet-dog shake behavior in the Icilin (HY-11062)-induced wet-dog shake SpragueDawley rat model, demonstrating that AMG 333 effectively blocks the TRPM8 target[1].
AMG 333 (1-3 mg/kg, p.o., single dose) dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation SpragueDawley rat model, indicating that AMG 333 effectively acts on the TRPM8 target[1]. | Animal Model: | Icilin (HY-11062)-induced wet-dog shake (WDS) behavior in SpragueDawley rat model[1] | | Dosage: | 0.6, 1, 3 mg/kg | | Administration: | Oral gavage (p.o.), single dose | | Result: | Demonstrated significant dose-dependent inhibition;
3 mg/kg fully inhibited WDS. |
| Animal Model: | Cold stimulation-induced blood pressure elevation SpragueDawley rat model[1] | | Dosage: | 1, 3 mg/kg | | Administration: | Oral gavage (p.o.), single dose | | Result: | Showed significant inhibition of cold-induced blood pressure elevation at 1 mg/kg and 3 mg/kg;
3 mg/kg fully blocked cold-pressor response. |
| | storage | Store at -20°C | | References | [1] Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. DOI:10.1021/acs.jmedchem.8b00518 |
| | AMG-333 Preparation Products And Raw materials |
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