BAY-885 manufacturers
- BAY885
-
- $46.00 / 1mg
-
2025-04-29
- CAS:2307249-33-6
- Min. Order:
- Purity: 99.83%
- Supply Ability: 10g
- BAY885
-
- $46.00 / 1mg
-
2025-04-29
- CAS:2307249-33-6
- Min. Order:
- Purity: 99.83%
- Supply Ability: 10g
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| Product Name: | BAY-885 | | Synonyms: | BAY-885;[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone;Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-;BAY-885 USP/EP/BP;BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885;BAY885, 10 mM in DMSO | | CAS: | 2307249-33-6 | | MF: | C25H28F3N7O2 | | MW: | 515.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2307249-33-6.mol |  |
| | BAY-885 Chemical Properties |
| Boiling point | 685.0±55.0 °C(Predicted) | | density | 1.362±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM) | | form | A solid | | pka | 7.06±0.42(Predicted) | | color | White to light yellow |
| | BAY-885 Usage And Synthesis |
| Use | BAY-885 is a highly potent and selective ERK5 inhibitor. | | In vitro | BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation. | | Uses | BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1]. | | Biological Activity | BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μM ATP; % inhibition at 1 μM = 62/r at Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4 affinity (20 μM), nor inhibitory potency toward hERG (10 μM) and CYP enzymes (20 μM; CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4). BAY-885 potently inhibits 100 ng/mL EGF-induced, ERK5-dependent MEF2 activity (IC50 = 120 nM; SN12C-MEF2-luc reporter assay). | | IC 50 | ERK5: 35 nM (IC50) | | References | [1] Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62(2):928-940. DOI:10.1021/acs.jmedchem.8b01606 |
| | BAY-885 Preparation Products And Raw materials |
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