|
|
| | BRD9526 Basic information |
| Product Name: | BRD9526 | | Synonyms: | BRD9526;Cyclopropanecarboxamide, N-[(2R,3S)-2-[[[(2,4-dichlorophenyl)sulfonyl]methylamino]methyl]-3,4,5,6-tetrahydro-5-[(1R)-2-hydroxy-1-methylethyl]-3-methyl-6-oxo-2H-1,5-benzoxazocin-10-yl]- | | CAS: | 1446352-30-2 | | MF: | C26H31Cl2N3O6S | | MW: | 584.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1446352-30-2.mol |  |
| | BRD9526 Chemical Properties |
| density | 1.400±0.06 g/cm3(Predicted) | | pka | 13.88±0.60(Predicted) |
| | BRD9526 Usage And Synthesis |
| Description | BRD-9526 is a potent and selective Sonic Hedgehog (Shh) inhibitor. The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. | | Uses | BRD-9526 is a potent and selective Sonic Hedgehog (Shh) pathway inhibitor with potential anti-cancer activity. The mechanism of BRD-9526 is similar in some ways to commonly used inhibitors such as cyclopamine, but is significantly different in other ways. The discovery of BRD-9526 may provide a useful probe for studying complex signaling pathways[1]. | | References | [1] Discovery of small-molecule modulators of the Sonic Hedgehog pathway DOI:10.1021/ja400034k |
| | BRD9526 Preparation Products And Raw materials |
|