| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
NAcM-OPT manufacturers
- NAcM-OPT
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-
2026-08-11
- CAS:2089293-61-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
- NAcM-OPT
-
- $48.00
-
2026-07-27
- CAS:2089293-61-6
- Purity: 99.93%
- Supply Ability: 10g
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| | NAcM-OPT Basic information |
| Product Name: | NAcM-OPT | | Synonyms: | NAcM-OPT; NAcM-OPT NEW;Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-;E3 ligating enzyme,Ubiquitin activating enzyme,inhibit,NAcM-OPT,NAE,Ubiquitin conjugating enzyme,NAcMOPT,Ubiquitin ligase,NEDD8-activating Enzyme,E1 activating enzyme,E2 conjugating enzyme,Inhibitor,NAcM OPT,E1/E2/E3 Enzyme;NAcM-OPT, 10 mM in DMSO | | CAS: | 2089293-61-6 | | MF: | C23H29Cl2N3O | | MW: | 434.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2089293-61-6.mol |  |
| | NAcM-OPT Chemical Properties |
| Boiling point | 589.8±50.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml) | | pka | 13.30±0.70(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year as from date of purchase supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | NAcM-OPT Usage And Synthesis |
| Description | NAcM-OPT (2089293-61-6) is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1 | | Uses | NAcM-OPT inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line. | | Definition | ChEBI: 1-Benzyl-1-(1-butyl-4-piperidinyl)-3-(3,4-dichlorophenyl)urea is a member of ureas. | | References | [1] DANIEL C SCOTT. Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase[J]. Nature chemical biology, 2017, 13 8: 850-857. DOI:10.1038/nchembio.2386
[2] DANIEL C. SCOTT. N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex[J]. Science, 2011, 334 6056. DOI:10.1126/science.1209307 |
| | NAcM-OPT Preparation Products And Raw materials |
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