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| | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Basic information | | Uses |
| Product Name: | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER | | Synonyms: | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER;3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER;Methyl 2-fluoro-4-iodopyridine-3-carboxylate;Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine;Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate;2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester;Methyl 2-Fluoro-4-iodonicotinate | | CAS: | 884494-84-2 | | MF: | C7H5FINO2 | | MW: | 281.02 | | EINECS: | | | Product Categories: | Boronic Acid;Heterocyclic Compounds | | Mol File: | 884494-84-2.mol |  |
| | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Chemical Properties |
| Boiling point | 287℃ | | density | 1.913 | | Fp | 127℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | -3.86±0.18(Predicted) | | Appearance | White to off-white Solid |
| | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Usage And Synthesis |
| Uses | 2-Fluoro-4-iodonicotinic acid methyl ester can be used as a pharmaceutical synthesis intermediate. | | Synthesis | GENERAL STEPS: 2-Fluoro-4-iodonicotinic acid (5.13 g) was dissolved in a solvent mixture of ether (25 mL) and methanol (25 mL) under nitrogen protection. To this solution was slowly added a 10% hexane solution of trimethylsilylated diazomethane (32.9 g). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford methyl 2-fluoro-4-iodonicotinate (5.3 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.94 (3H, s), 7.98 (1H, dd, J = 5.3, 1.1 Hz), 8.07 (1H, dd, J = 5.3, 0.8 Hz). | | References | [1] Patent: EP2921480, 2015, A1. Location in patent: Paragraph 0391; 0392
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63 |
| | 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER Preparation Products And Raw materials |
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