- GNE-6640
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- $64.00 / 1mg
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2026-01-28
- CAS:2009273-67-8
- Min. Order:
- Purity: 99.59%
- Supply Ability: 10g
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| | GNE-6640 Basic information |
| Product Name: | GNE-6640 | | Synonyms: | CS-2824;GNE-6640;GNE 6640;GNE6640;2009273-67-8;Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-;GNE-6641;Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640;4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol;GNE-6640, 10 mM in DMSO | | CAS: | 2009273-67-8 | | MF: | C20H18N4O | | MW: | 330.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2009273-67-8.mol |  |
| | GNE-6640 Chemical Properties |
| Boiling point | 595.5±50.0 °C(Predicted) | | density | 1.308±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:1.0(Max Conc. mg/mL);3.03(Max Conc. mM)
DMSO:3.0(Max Conc. mg/mL);9.08(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM) | | form | A solid | | pka | 8.23±0.15(Predicted) | | color | White to off-white |
| | GNE-6640 Usage And Synthesis |
| Uses | GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2]. | | References | [1] Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538. DOI:10.1038/nature24006
[2] Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639. DOI:10.1007/s00280-020-04046-8 |
| | GNE-6640 Preparation Products And Raw materials |
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