PF-06733804

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PF-06733804
CAS:1873373-33-1
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:PF-06733804
CAS:1873373-33-1
Package:50mg;2380USD|25mg;1820USD|100mg;3100USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PF-06733804
CAS:1873373-33-1
Package:50mg;2380USD|25mg;1820USD|100mg;3100USD
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Email: 3003855609@qq.com
Products Intro: Product Name:PF-06733804
CAS:1873373-33-1
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:PF-06733804
CAS:1873373-33-1
Purity:>=98% (HPLC) Package:25MG Remarks:PZ0341-25MG

PF-06733804 manufacturers

  • PF-06733804
  • PF-06733804 pictures
  • $2380.00
  • 2026-04-20
  • CAS:1873373-33-1
  • Purity:
  • Supply Ability: 10g
  • PF-06733804
  • PF-06733804 pictures
  • $2380.00
  • 2025-07-17
  • CAS:1873373-33-1
  • Purity:
  • Supply Ability: 10g
PF-06733804 Basic information
Product Name:PF-06733804
Synonyms:PF-06733804;Trk-IN-3;PF-06733804 >=98% (HPLC);PF06733804,PF 06733804;3-Pyridinecarboxamide, 6-amino-5-[[(3S)-4,4-difluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]-3-pyrrolidinyl]oxy]-N-methyl-
CAS:1873373-33-1
MF:C20H19F5N4O4
MW:474.38
EINECS:
Product Categories:
Mol File:1873373-33-1.mol
PF-06733804 Structure
PF-06733804 Chemical Properties
Boiling point 607.6±55.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: 20mg/mL, clear
form powder
pka14.08±0.46(Predicted)
color white to beige
InChIKeyFTAFQADCGCSJAH-HNNXBMFYSA-N
SMILESNC1=C(O[C@H]2CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2(F)F)C=C(C(NC)=O)C=N1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
PF-06733804 Usage And Synthesis
UsesPF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
Biochem/physiol ActionsPF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor.
IC 50TrkA: 8.4 nM (IC50, in cell-based assays); TrkB: 6.2 nM (IC50, in cell-based assays); TrkC: 2.2 nM (IC50, in cell-based assays)
References[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633
PF-06733804 Preparation Products And Raw materials
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