1638504-66-1
| 中文名称 | 1638504-66-1 |
|---|---|
| 中文同义词 | 化合物 T11568;化合物 HIV-1 INTEGRASE INHIBITOR 4 |
| 英文名称 | HIV-1 integrase inhibitor 4 |
| 英文同义词 | HIV-1 integrase inhibitor 4;1,8-Naphthyridine-3-carboxamide, 4-amino-N-[(2,4-difluorophenyl)methyl]-1,2-dihydro-1-hydroxy-2-oxo-6-[2-(phenylsulfonyl)ethyl]-;HIV1 integrase inhibitor 4,HIV 1 integrase inhibitor 4 |
| CAS号 | 1638504-66-1 |
| 分子式 | C24H20F2N4O5S |
| 分子量 | 514.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1638504-66-1.mol |
| 结构式 |  |
1638504-66-1 性质
| 密度 | 1.517±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.80±0.60(Predicted) |
HIV-1 integrase inhibitor 4 是一种 HIV-1 整合酶链转移 (INST) 抑制剂，其 IC50 值为 3.7 nM。
IC50: 3.7 nM (INST)
HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC 50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations.